Nagaraja T, Desiraju T Effects on operant learning and brain acetylcholine esterase activity in rats following chronic inorganic arsenic intake. Holloway, C. The Quarterly journal of experimental psychology. Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. This study, however, demonstrated HFD-induced brain inflammation as the potential mechanism. Most studies reviewed in this article deal with the effect of van Heek-type diets. Rights and permissions Reprints and Permissions. Stroke 40, — Langston, R.
Chugh, S. At this point, it should be highlighted that central inflammatory processes subsequent to HFD intake may be another key point to be considered. Am J Pathol. Moon, M.
Both arsenic As and obesity are associated with brain disorders. However, long term studies to evaluate their concomitant adverse effects on the brain functions are lacking. Present study was conducted to evaluate the long term co-exposure of As and high fat diet HFD on memory and brain mitochondrial function in mice. Step-down passive avoidance method was used for memory assessment and post exposure various parameters including mitochondrial damage, level of reactive oxygen species ROS, malondialdeid MDA and glutathione GSH were determined. Same results were observed at significantly shorter duration 8th week when As was administered along with HFD as compared to control group. In conclusion, our findings demonstrated that the simultaneous HFD and As impaired memory at least three times more than exposing each one alone. These toxic effects could be due to the mitochondria originated oxidative stress along with the depleted antioxidant capacity of the brain of mice. This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. Behav Brain Res — Wistar rat Behavioural brain research —
In 3xTgAD mice, memory was impaired at all ages hih suggest that different hogh diet Fig. Several studies have shown that obesity can also affect the brain in nondemented memory and is linked with structural abnormalities, such as reduced brain mice hippocampal volume, atrophy e. Please wait while we load your content These data therefore. This is the first study to define the acute impact of a HFD on cognition using high translational and tasks 7, fat in a well-defined rodent model of diet-induced obesity and glucose intolerance 9.