Methods: The mice were fed either a normal diet or HFD for 12 weeks. Results: Lipid profiles from plasma and liver significantly improved in OR mice relative to the OP group. Energy expenditure was greater in OR mice than in OP mice, with a simultaneous decrease in body fat mass. Epididymal white adipose tissue eWAT and liver were enlarged in OP mice with visible immune-cell infiltration, but these effects were attenuated in OR mice compared with OP mice. Overall glucose metabolism was enhanced in OR mice compared with OP mice, including homeostasis model assessment for insulin resistance, plasma glucose and insulin concentrations, glucokinase activity and hepatic glycogen. Plasma adipokines and proinflammatory cytokines were upregulated in OP mice, and these changes were attenuated in OR mice. There were substantial differences between OP and OR mice in molecular pathways, including atherosclerosis signaling, sperm motility, cAMP-mediated signaling in eWAT; and fibrosis, agranulocyte adhesion and diapedesis, and atherosclerosis signaling in liver. Publication types Research Support, Non-U. Substances RNA, Messenger.
Glucosephosphatase flux in vitro is increased in type 2 diabetes. J Proteome Res ; 10 : — Cell Physiol Biochem ; 27 : — In the present study, we analyzed transgenerational changes in metabolic phenotypes in these 2 mouse colonies to explore how the distinct phenotypes have emerged through the repetitive selection. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. J Physiol ; : — Diet-induced obesity in rats leads to a decrease in sperm motility.
Obesity Reviews The mice were fed either a normal diet or HFD for 12 weeks. Reprints and Permissions. Substances Dietary Fats. Advanced search. J Proteome Res ; 10 : — Methods: The mice were fed either a normal diet or HFD for 12 weeks. Search Article Search Search.